Synthesis of Proteasome Inhibitor 6-Deoxy-Omuralide and Its Enantiomer Using Stereoselective Alkylation of Substituted Proline Ester

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01053G, PaperFeng Li, Voker J äger A potent 20S proteasome inhibitor, 6-deoxy-omuralide was stereoselectively synthesized in 20 steps with 5.1% overall yield staring from a chiral boron agent and D-glyceraldehyde acetonide. The stereoselective alkylation of the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research