Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats

Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the osteochondral junction in human and rat knees associates with OA pain.

Source: Osteoarthritis and Cartilage - May 24, 2020 Category: Rheumatology Authors: Koji Aso, Seyed Mohsen Shahtaheri, Roger Hill, Deborah Wilson, Daniel F. McWilliams, Lilian N. Nwosu, Victoria Chapman, David A. Walsh Source Type: research