Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15  N NMR spectroscopy

Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a str...

Source: BMC Cell Biology - May 25, 2020 Category: Cytology Authors: Peter Agback, Esmeralda Woestenenk and Tatiana Agback Tags: Research article Source Type: research