Targeted Alpha Therapy: a critical review of translational dosimetry research with emphasis on Actinium-225.

Targeted Alpha Therapy: a critical review of translational dosimetry research with emphasis on Actinium-225. Q J Nucl Med Mol Imaging. 2020 May 21;: Authors: Seoane DC, De Saint-Hubert M, Crabbe M, Struelens L, Koole M Abstract This review provides a general overview of the current achievements and challenges in translational dosimetry for Targeted Alpha therapy (TAT). The concept of Targeted Radionuclide Therapy (TRNT) is described with an overview of its clinical applicability and the added value of TAT is discussed. For TAT, we focused on 225Ac (actinium-225) as an example for alpha particle emitting radionuclides and their features, such as limited range within tissue and high linear energy transfer, which make alpha particle emissions more effective in targeted killing of tumour cells compared to beta radiation. Starting with the state-of-the-art dosimetry for TRNT and TAT, we then describe the challenges that still need to be met in order to move to a personalized dosimetry approach for TAT. Specifically for 225Ac, we discuss the recoiled daughter effect which may provoke significant damage to healthy tissue or organs and should be considered. Next, a broad overview is given of the pre-clinical research on 225Ac-TAT with an extensive description of tools which are only available in a pre-clinical setting and their added value. In addition, we review the preclinical biodistribution and dosimetry studies that have been performed ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research