TLR4 regulates ROS and autophagy to control neutrophil extracellular traps formation against Streptococcus pneumoniae in acute otitis media.

CONCLUSIONS: TLR4 regulates ROS and autophagy to control NETs formation against S.pn in the course of AOM.
IMPACT: S.pn can induce NETs formation in vitro and in vivo; TLR4 regulates NETs formation by ROS and autophagy; NETs contribute to the clearance of bacteria in acute otitis media.In this study, we firstly found that autophagy and ROS were required for S.pn-induced NETs formation in the model of acute otitis media (AOM). And to some extent, TLR4 mediated NETs formation during AOM.Our research might provide a potential strategy for the treatment of otitis media.
PMID: 32438368 [PubMed - as supplied by publisher]

Source: Pediatric Research - May 20, 2020 Category: Pediatrics Authors: Dong Y, Jin C, Ding Z, Zhu Y, He Q, Zhang X, Ai R, Yin Y, He Y Tags: Pediatr Res Source Type: research