On-chip estimation of hematocrit level for diagnosing anemic conditions by Impedimetric techniques.

On-chip estimation of hematocrit level for diagnosing anemic conditions by Impedimetric techniques. Biomed Microdevices. 2020 May 20;22(2):38 Authors: Chakraborty S, Das S, Das C, Chandra S, Sharma KD, Karmakar A, Chattoapadhyay S Abstract An on-chip device has been fabricated on Si platform for precise estimation of the hematocrit (Hct) level of human blood with rapid turn out. Impedance/capacitance spectroscopy and current-voltage (I-V) measurements have been employed to observe the variation of electrical parameters of erythrocyte suspensions with varying Hct level. Experimentally obtained values of capacitance, impedance and conductance with Hct level suggests a linear variation. Current-time measurement has also been performed to ensure the susceptibility of red blood cells under a fixed external electric field for certain duration of time. The online real time sample analyzes have also been performed by the device connected with an embedded electronic circuit interfaced with a laptop through appropriate software. This has enabled the development of a novel Si-chip based compact point-of-care (POC) diagnosis system for Hct level estimation by measuring the dielectric/capacitive variation of an erythrocyte cell suspension. The relevant performance parameters of such a compact system including range, resolution, limit of detection and throughput have also been evaluated. PMID: 32430696 [PubMed - in process]
Source: Biomedical Microdevices - Category: Biomedical Engineering Authors: Tags: Biomed Microdevices Source Type: research