Comment on: Outcome of Bariatric Surgery on Hypothyroidism: Experience from a Tertiary Care Centre in India

Obesity and subclinical hypothyroidism are two very common clinical conditions with high prevalence in the general population [1]. Although it is generally thought that hypothyroidism causes obesity, it is now accepted that elevation of thyroid stimulating hormone (TSH) is secondary to obesity with positive correlation between body mass index (BMI) and TSH plasma levels [1]. Many studies have shown a direct positive correlation between TSH plasma levels and weight gain [2,3]. To this regard it has been always matter of debate if hypothyroidism as evidenced by TSH increase determines weight gain or the opposite given the fact that leptin, the main protein hormone produced and secreted by adipose tissue, modulates TSH secretion interfering with the hypothalamic TRH secretion [4].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research