Asymmetric N-aminoalkylation of 3-substituted indoles by N-protected N,O-acetals: an access to chiral propargyl aminals

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00795A, CommunicationJunxian Yang, Zeyuan He, Liang Hong, Wangsheng Sun, Rui Wang A direct enantioselective N1 aminoalkylation of 3-substituted indoles is efficiently catalyzed by a phosphoric acid catalyst under mild conditions, which could be applied to the modification of tryptophan containing oligopeptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research