The effect of hydrostatic pressure on proteoglycan production in articular cartilage in vitro: a meta-analysis

In previous research the use of hydrostatic pressure (HP) has been applied to enhance the formation of engineered cartilage, through the up-regulation of proteoglycan synthesis by mechanotransduction. However, the HP stimulation approach has been shown to vary between studies with a wide disparity in results, including anabolic, catabolic and non-responsive outcomes. To this end, a meta-analysis of HP publications using 3D cultured chondrocytes was performed to elucidate the key experiment factors involved in achieving a mechanotransducive response.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Review Source Type: research