Disparities in Genetic Testing and Care Among Black Women with Hereditary Breast Cancer

AbstractPurpose of ReviewDespite a steady improvement in breast cancer survival rates over the past several decades, mortality disparities remain among Black women, who have a 42% higher death rate compared to non-Hispanic white (NHW) women. Hereditary breast cancer (HBC) accounts for 5 –10% of all breast cancer cases, the majority of which are due to theBRCA1 andBRCA2 (BRCA) genes. Despite the availability ofBRCA testing for over 25  years, there remain disproportionately lower rates of genetic testing among Blacks compared to NHW due to a multitude of factors. The intent of this review is to discuss racial disparities focused on HBC across diverse populations and review the existing gaps to be addressed when delivering gene-b ased care.Recent FindingsThe factors contributing to the racial survival disparity are undoubtedly complex and likely an interplay between tumor biology, genomics, patterns of care, and socioeconomic factors. Advances in genomic technologies that now allow for full characterization of germline DNA sequencing are integral in defining the complex and multifactorial cause of breast cancer and may help to explain the existing racial survival disparities.SummaryIdentification of inherited cancer risk may lead to cancer prevention, early cancer detection, treatment guidance, and ultimately has great potential to improve outcomes. Consequently, advances in HBC diagnosis and treatment without widespread implementation have the potential to further widen the...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research