Increased expression of dermal LL37 may trigger migration of CCR7+ regulatory T cells in extramammary Paget ’s disease

LL37 is an autoantigen derived from keratinocytes that can bind to surface scavenger receptors expressed on myeloid dendritic cells (DCs), plasmacytoid DCs, and macrophages to recognize extracellular self-DNA [1]. Among such scavenger receptors, CD163 is a specific surface marker of macrophages [2]. The expression of LL37 on myeloid cells in the dermis is controlled by proinflammatory cytokines such as IL-17 and TNF- α [3]. Since Paget’s cells produce CCL20 and recruit Th17 in the lesional skin of EMPD [4], the expression of LL37 in invasive EMPD might be increased after the dermal invasion of Paget’s cells.

Source: Journal of Dermatological Science - May 15, 2020 Category: Dermatology Authors: Chunbing Lyu, Taku Fujimura, Ryo Amagai, Kentaro Ohuchi, Yota Sato, Kayo Tanita, Shigeto Matsushita, Yasuhiro Fujisawa, Atsushi Otsuka, Yuki Yamamoto, Toshiya Takahashi, Setsuya Aiba Tags: Letter to the Editor Source Type: research