Diverse functionalization of strong alkyl C-H bonds by undirected borylation

We report an iridium catalyst ligated by 2-methylphenanthroline with activity that enables, with the substrate as limiting reagent, undirected borylation of primary C–H bonds and, when primary C–H bonds are absent or blocked, borylation of strong secondary C–H bonds. Reactions at the resulting carbon-boron bond show how these borylations can lead to the installation of a wide range of carbon-carbon and carbon-heteroatom bonds at previously inaccessible positions of organic molecules.

Source: ScienceNOW - May 13, 2020 Category: Science Authors: Oeschger, R., Su, B., Yu, I., Ehinger, C., Romero, E., He, S., Hartwig, J. Tags: Chemistry r-articles Source Type: news