COVID-19 May Trigger Rare Complication In Children

As COVID-19 continues to spread, there is growing evidence that children may be vulnerable to a rare but serious complication triggered by the infection that has features of Kawasaki disease and toxic shock syndrome.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized condition affecting children with recent infection or exposure to coronavirus disease 2019 (COVID-19). MIS-C has symptoms that affect multiple organs systems, with some clinical features resembling Kawasaki disease (KD) and toxic shock syndrome (TSS).
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Clinical Review Source Type: research
We report a 22-year-old Indian male, with five days of fever, headache, myalgia, skin rash and one day history of lower extremity and upper abdominal pain, and vomiting. COVID-19 Reverse transcriptase polymerase chain reaction (RT-PCR) at admission was negative.PMID:34115386 | DOI:10.1111/bjd.20574
Source: The British Journal of Dermatology - Category: Dermatology Authors: Source Type: research
AbstractWith growing number of pediatric cases of COVID-19, a unique hyper-inflammatory syndrome, linked to SARS-CoV-2 infection, has emerged in children referred to as multisystem inflammatory syndrome in children (MIS-C). This Kawasaki Disease (KD)-like illness has been described across the world. This syndrome shares features of KD, toxic shock syndrome, and macrophage activation syndrome and is associated with significantly elevated inflammatory markers. Everyday there are new data emerging improving the care of these patients. The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) is a collaborative networ...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Background: COronaVIrus Disease 2019 (COVID-19) affects children with less severe symptoms than adults. However, severe COVID-19 paediatric cases are increasingly reported, including patients with Kawasaki disease (KD) or a multisystem inflammatory syndrome (MIS-C) that can present with features resembling KD.Summary: MIS-C is an emerging severe paediatric syndrome associated with COVID-19 that can show overlapping features of KD, KD shock syndrome, and toxic shock syndrome. MIS-C might be an inflammatory disease distinct from KD resulting from an exaggerated immune response. A high prevalence of mucocutaneous manifestatio...
Source: Dermatology - Category: Dermatology Source Type: research
Indian J Clin Biochem. 2021 Mar 6:1-12. doi: 10.1007/s12291-021-00963-4. Online ahead of print.ABSTRACTThe pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) with a phenotype resembling Kawasaki disease (KD) ('Kawa-COVID-19'). Features of this newly recognized condition may include fever, hypotension, severe abdominal pain and cardiac dysfunction, evidence of inflammation, and single or m...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Source Type: research
Paediatr Int Child Health. 2021 Feb 22:1-9. doi: 10.1080/20469047.2021.1888026. Online ahead of print.ABSTRACTDespite the worldwide spread of SARS-CoV-2 infection (COVID-19), knowledge of the different clinical presentations, ways of transmission, severity and prognosis in children and adolescents is limited. An increasing number of reports describe some of these characteristics in this age range. A non-systematic review was undertaken using MEDLINE (PubMed), LILACS (VHL), Scopus, Web of Science, Cochrane and CAPES Portal databases from 1 January until 30 September 2020 [103] with the search terms SARS-CoV-2, COVID-19, chi...
Source: Paediatrics and international child health - Category: Pediatrics Authors: Source Type: research
Paediatr Drugs. 2021 Jan 22:1-11. doi: 10.1007/s40272-020-00435-x. Online ahead of print.ABSTRACTAlthough data on the incidence and severity of new coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection showed more significant disease among adults and the elderly, a clinical manifestation characterized by a multisystem inflammatory syndrome was described in children (MIS-C). It was initially thought to be specific to children, but recent reports have shown that it can also occur in adults. MIS-C is characterized by a number of multisystemic manifestations resemblin...
Source: Paediatric Drugs - Category: Pediatrics Authors: Source Type: research
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