Mangafodipir treatment for oxaliplatin-associated neuropathy

An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must be balanced with prevention of neuropathies. Currently, there are no therapeutic interventions available to relieve oxaliplatin-associated neurological symptoms, which are thought to be a result of reactive oxygen species-associated damage.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

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Authors: Procaccio L, Bergamo F, Manai C, Di Antonio V, Fassan M, Zagonel V, Lonardi S, Loupakis F Abstract Introduction: Lung metastases occur in 10-20% of patients with colorectal cancer (CRC). Most of them are treated with palliative intent and have a poor prognosis. Pulmonary metastasectomy may be a curative option for carefully selected patients with 5-year survival rates ranging from 25% to 60%. However, up to 70% of patients develop recurrence after pulmonary metastasectomy. Therefore, the identification of prognostic factors is essential in CRC patients with resectable lung metastases. Areas covered: This r...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: July 2019Source: Microchemical Journal, Volume 148Author(s): Shekher Kummari, V. Sunil Kumar, M. Satyanarayana, K. Vengatajalabathy GobiAbstractChemotherapy is a widely used effective method for the treatment of cancer in humans. Severity of dose levels and treatment duration necessitate frequent continuous monitoring of active drug concentration in human serum and urine. Development of an electrochemical biosensor for direct determination of methotrexate (MTX), a chemotherapy agent, from physiological fluids has been investigated. Functionalized multi-walled carbon nanotube paste electrodes (f-CNTPE) hav...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Conclusion Methodology60ml of peripheral venous blood was withdrawn from 9 patients (M=5, F=4) with mean age of 62±11 years old and 1 healthy donor (male, 45 years) using simple venipuncture technique. The samples were isolated and induced using interferon-gamma (IFN-γ), anti-CD3 antibody, recombinant human interleukin-2 (IL-2) for up to 21 days.ResultsWe successfully isolated and expanded CIK from all 10 blood samples. The number of CIK was significantly increased from Day 1 to Day 21 of cell expansion (0.12±0.08 × 109 vs. 7.46±1.85 × 109 cells, p
Source: Cytotherapy - Category: Cytology Source Type: research
The U.S. Food &Drug Administration on Thursday approved Tumor Treating Fields, a therapy involving electric currents that disrupt cancer cell division and inhibit tumor growth, for the first-line treatment of malignant pleural mesothelioma. It is the first treatment in more than 15 years that the FDA approves for mesothelioma. In 2004, the agency added the chemotherapy drug pemetrexed (Alimta) to standard-of-care treatment. The FDA approved Novocure’s NovoTTF-100L System under the agency’s Humanitarian Device Exemption. The approval comes eight months after Novocure, which manufactures and markets the devi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Authors: Yoo RN, Kim HJ Abstract Standard use of neoadjuvant chemoradiotherapy, total mesorectal excision, and postoperative adjuvant chemotherapy in locally advanced rectal cancer has tremendously improved oncologic outcomes over the past several decades. However, these improvements come with costs of significant morbidity and poor quality of life. Along with developments in imaging techniques, clinical experience and evidence have identified a certain subgroup of patients that have exceptionally good clinical outcomes while preserving quality of life. Driven by patient demand and interest in preserving quality of...
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Authors: Espelt MV, Bacigalupo ML, Carabias P, Troncoso MF Abstract Hepatocellular carcinoma (HCC) has an elevated mortality rate, largely because of high recurrence and metastasis. Additionally, the main obstacle during treatment of HCC is that patients usually develop resistance to chemotherapy. Cancer drug resistance involves many different mechanisms, including alterations in drug metabolism and processing, impairment of the apoptotic machine, activation of cell survival signaling, decreased drug sensitivity and autophagy, among others. Nowadays, miRNAs are emerging as master regulators of normal physiology- an...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Authors: Sun W, Shen NM, Fu SL Abstract Cervical cancer (CC) develops, after human papillomavirus (HPV), an infection transmitted through sexual contact. Worldwide estimates are around>500,000 CC diagnoses and>300,000 related deaths annually, and CC remains the second most devastating type of cancers in women after breast cancer. Although the vaccine against HPV has reduced the incidence of infection and the treatment efficacy of the early-stage diagnoses has improved, many challenges remain in terms of treatment efficacy, during the late-stage and prevention of chemotherapy resistance development. Thus, new ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Kunitomi A, Hasegawa Y, Lmamura J, Yokomaku Y, Tokunaga T, Miyata Y, Iida H, Nagai H Abstract Acute promyelocytic leukemia (APL) in human immunodeficiency virus (HIV)-infected individuals is very rare. There is currently no consensus regarding the use of anti-cancer drugs with highly active anti-retroviral therapy (ART) in these patients due to their small number. We herein report two cases of APL with HIV-infected patients. Both cases received all-trans-retinoic acid-containing chemotherapies and achieved complete remission. ART was continued throughout the treatment course. The clinical course of these c...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: Prognosis in advanced stage CCA is still very poor. However, multimodal treatment in palliative patients significantly prolong survival.Digestion
Source: Digestion - Category: Gastroenterology Source Type: research
ConclusionAt 2 years, the exercise groups were generally experiencing positive differences in cancer-related fatigue (RT-HIIT), symptoms (AT-HIIT), and muscle strength (RT-HIIT) to UC. The findings provide novel evidence that being involved in an exercise program during chemotherapy can have long-term benefits for women with breast cancer, but that strategies are needed to create better pathways to support patients to maintain physical activity levels.Trial registration number: NCT02522260. Trial registered on 9 June 2015. Retrospectively registered.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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