Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours
British Journal of Cancer, Published online: 11 May 2020; doi:10.1038/s41416-020-0878-7Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours
Contributor : Oliver DorigoSeries Type : Expression profiling by arrayOrganism : Mus musculusWe used mouse Clariom-S microarrays to study the gene expression profile of ID8 cancer cells stimulated with C-C Chemokine Ligand 6 (CCL6).
Publication date: Available online 3 July 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): B. Toubhans, A.T Gourlan, P. Telouk, K. Lutchman-Singh, L.W. Francis, R.S. Conlan, L. Margarit, D. Gonzalez, L. Charlet
Cancers, Vol. 12, Pages 1801: Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review Cancers doi: 10.3390/cancers12071801 Authors: Ludwika Piwowarczyk Maciej Stawny Dariusz T. Mlynarczyk Izabela Muszalska-Kolos Tomasz Goslinski Anna Jelińska The incidence of bladder cancer (BC) is increasing, and although current therapeutic approaches are effective in many cases, recurrence of BC is common. Therefore, it seems necessary to search not only for novel therapeutic approaches, but also for new therapeutic agents. Natural polyphenols, such as curcumin (CUR) and epiga...
Contributors : Fangfang Song ; Baifeng ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensAltered methylation patterns in HGSOC were further characterized by gene expression profiles. By integrating DNA methylation and mRNA expression data, we identified genes with negative and positive correlation, aiming to identify molecular drivers and pathways that are HGSOC-related.
The purpose of this study was to explore the efficacy and tolerability of poly ADP-ribose polymerase (PARP) inhibitors in patients with ovarian cancer.
Publication date: Available online 3 July 2020Source: Clinica Chimica ActaAuthor(s): Boddapati Kalyani Bhardwaj, Sanu Thankachan, Thejaswini Venkatesh, Padmanaban S. Suresh
Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
Authors: Moffat GT, O'Reilly EM Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that remains a challenge to treat. In pursuit of personalized medicine, researchers continue active exploration of the genetic and molecular framework of PDAC to apply novel therapeutics and enhance outcomes. In patients who have PDAC, germline mutations-such as those in the BRCA1/2 and PALB2 genes-are predominantly associated with the DNA damage response and repair pathway. On the basis of studies completed in patients with BRCA-mutated advanced breast and ovarian cancer, the poly(ADP-ribose) polymerase (PA...
Conclusions: Our results highlight the role of WNT/PCP signaling in ovarian cancerogenesis, indicate a possible therapeutic potential of CK1 inhibitors for HGSC, and strongly suggest that the detection of WNT pathway inducing activity ascites (or WNT5A levels in ascites as a surrogate marker) could be a novel prognostic tool for HGSC patients.
Conclusion: Our findings provided an effective strategy to compensate for the congenital defects of some small molecule inhibitors and thus enhanced the therapeutic efficacy of ovarian cancer.