RANKL expression of primary osteoblasts is enhanced by an IL-17-mediated JAK2/STAT3 pathway through autophagy suppression.

Conclusion: Overall, our findings demonstrate, for the first time, that IL-17 modulates RANKL expression of osteoblasts through an autophagy-JAK2-STAT3 signaling pathway, thus affecting bone metabolism. PMID: 32370570 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32370570?dopt=Abstract

Source: Connective Tissue Research - May 8, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

More News: Research | Study