HOTAIR Competitively Binds MiRNA330 as a Molecular Sponge to Increase the Resistance of Gastric Cancer to Trastuzumab.

CONCLUSION: HOTAIR can not only promote tumor proliferation, but also enhances the resistance of tumor cells to drugs. Our experimental data not only showed strong expression of HOTAIR in gastric cancer, but also that strong expression of HOTAIR caused the sensitivity of gastric cancer cells to trastuzumab, which is a useful reference for postoperative medication.
PMID: 32364078 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - May 3, 2020 Category: Cancer & Oncology Authors: Bie L, Luo S, Li D, Wei Y, Mu Y, Chen X, Wang S, Guo P, Lu X Tags: Curr Cancer Drug Targets Source Type: research