Ultra-High Dose Rate Effect on Circulating Immune Cells: A Potential Mechanism for FLASH Effect?

FLASH radiotherapy (RT) delivers ultra-fast radiation treatment with a dose rate several orders of magnitude higher than conventional dose rates [1 –7]. It has been reported that FLASH-RT can significantly spare normal tissues in comparison to RT at conventional dose rates, whereas tumor responses are the same as or better than those resulting from conventional dose rate RT [1–7]. This FLASH effect has been demonstrated in various experimen tal animal models (mice, zebrafish, pigs, cats), various organs (lung, gut, brain, skin) and by various research groups [1–7].

Source: Radiotherapy and Oncology - May 4, 2020 Category: Radiology Authors: Jian-Yue Jin, Anxin Gu, Weili Wang, Nancy L. Oleinick, Mitchell Machtay, Feng-Ming (Spring) Kong Tags: Original Article Source Type: research