Dysregulation of microRNA expression in diabetic skin

Diabetes is a chronic metabolic disease whose incidence and prevalence are high and constantly growing [1]. It arises as consequence of increased glucose levels due to insulin unbalance or impaired responsiveness. The vast majority of diabetic patients suffers from type 2 diabetes due to insulin resistance, while 5-10% of patients are affected by type 1 insulin-dependent diabetes [1]. Clinical skin manifestations are common in diabetes, often being the first sign of the metabolic disorder [2]. They involve at least 30% of patients and include increased propensity to infections, hyperpigmentation, dermal thickening, spontaneous blister development and the highly invalidating foot ulcers.

Source: Journal of Dermatological Science - May 3, 2020 Category: Dermatology Authors: Enke Baldini, Erika Testa, Christine Voellenkle, Emanuela De Domenico, Francesca Cianfarani, Fabio Martelli, Salvatore Ulisse, Teresa Odorisio Source Type: research