Generation of Singlet Molecular Oxygen by Lipid Hydroperoxides and Nitronium Ion †

O2 (1Δg) is generated when lipid hydroperoxides (OAOOH, LAOOH and ChOOH) react with NO2+ AbstractSinglet molecular oxygen is a reactive species involved in biological oxidative processes. The major cellular targets of singlet molecular oxygen are unsaturated fatty acids in the membrane, as well as nucleic acids and proteins. The aim of this study was to investigate whether lipids and commercial hydroperoxides generate singlet molecular oxygen, in presence of nitronium and activated nitronium ion. For this purpose, monomol light emitted in the near ‐infrared region (λ = 1270 nm) was used to monitor singlet molecular oxygen decay in different solvents, with different hydroperoxides and in the presence of azide. Direct measurements of the singlet molecular oxygen spectrum at 1270 nm recorded during the reaction between lipids and commerci al hydroperoxides and nitronium ions unequivocally demonstrated the formation of this excited species.

Source: Photochemistry and Photobiology - May 3, 2020 Category: Science Authors: Fernanda M. Prado, Alexsandra C. Scalfo, Sayuri Miyamoto, Marisa H.G. Medeiros, Paolo Di Mascio Tags: Special Issue Research Article Source Type: research