Profile of drug-drug interactions (DIs) and impact on the effectiveness of antiretroviral therapy among patients living with HIV followed at an Infectious Diseases Referral Center in Belo Horizonte, Brazil.

The objectives of this study were to describe the profile of these interactions, their prevalence and their classification according to the potential for significant or non-significant DIs. From June 2015 to July 2016, PLWH on follow-up at an Infectious Diseases Referral Center in Belo Horizonte, Brazil have been investigated for the presence of DIs. A total of 304 patients were included and the majority (75%) had less than 50 years of age, male (66.4%), and 37.8% self-defined as brown skinned. Approximately 24% were on five or more medications and half of them presented with DIs. Patients older than 50 years had a higher frequency of ARVs DIs with other drugs compared to younger patients (p=0.002). No relationship was found between the number of DIs and the effectiveness of ARV. As expected, the higher the number of non-HIV medications used (OR=1.129; 95%CI 1.004-1.209; p=0.04) was associated with an increase in DIs. The high prevalence of DIs found and the data collected should be useful to establish measures of quaternary prevention and to increase the medication security for PLWH. PMID: 32360120 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - Category: Infectious Diseases Authors: Tags: Braz J Infect Dis Source Type: research