Evaluation of immunological parameters in diabetic patients: are these patients immunodeficient?

Evaluation of immunological parameters in diabetic patients: are these patients immunodeficient? Iran J Allergy Asthma Immunol. 2014 Apr;13(2):110-9 Authors: Moazezi Z, Hosseinian A, Ahmad Moazam E, Eslami MB, Mosavi E, Akhavan-Niaki H, Bijani A, Schloot N, Mostafazadeh A Abstract It has been widely thought that diabetic patients are prone to infections due to hyperglycemia induced immunodeficiency; the present study was designed to examine this opinion. In diabetic patients and normal control groups T-cell reactivity to hsp-60 molecule, tetanus toxoid recall antigen (TT) and phytohemagglutinin-A (PHA) mitogen were evaluated The number of circulating IFN-γ, IL-10 and IL-13 cytokine producing cells stimulated with above antigens or mitogen as well as the serum levels of Th1/Th2 type cytokines were determined. Total serum immunoglobulins (IgG, IgA, IgM), C3, C4 and CH50 were also measured. Diabetic patients showed a positive circulating T-cell reactivity to human recombinant hsp60 However, this reactivity was significantly lower in comparison to control group (p<0.001). All other examined factors were not significantly different between diabetic and normal subjects except for the number of IFN-γ and IL-13 producing cells in response to PHA stimulation, which was higher in control gtroup (p=0.006, 0.018, respectively).  The mean serum concentration of IgA in diabetic patients was 245.86±115.05 mg/dl versus 192.96±105.33 mg/dl in healt...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research