PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets

Nature Reviews Rheumatology, Published online: 27 April 2020; doi:10.1038/s41584-020-0409-1Peptidylarginine deiminases (PADs) citrullinate proteins, thereby creating the targets of the autoimmune response in rheumatoid arthritis; yet, in some individuals, PADs themselves can be the targets of immune responses. The mechanisms behind this complex relationship are unravelled in this Review.

http://feeds.nature.com/~r/nrrheum/rss/current/~3/yeGZtL4BOCw/s41584-020-0409-1

Source: Nature Reviews Rheumatology - April 26, 2020 Category: Rheumatology Authors: Ashley M. Curran Pooja Naik Jon T. Giles Erika Darrah Source Type: research

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