Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response

Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell ...

Source: BMC Immunology - April 21, 2020 Category: Allergy & Immunology Authors: Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp and Sudha Rao Tags: Review Source Type: research