Molecules, Vol. 25, Pages 1894: The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka

Molecules, Vol. 25, Pages 1894: The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka Molecules doi: 10.3390/molecules25081894 Authors: Mayuri Napagoda Jana Gerstmeier Hannah Butschek Sudhara De Soyza Simona Pace Sybille Lorenz Mallique Qader Sanjeeva Witharana Ajith Nagahawatte Gaya Wijayaratne Aleš Svatoš Lalith Jayasinghe Andreas Koeberle Oliver Werz Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Characterization of secondary metabolites was achieved by gas chromatography coupled to mass spectrometric (GC-MS) analysis. n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 µg/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 µg/mL) and mPGES-1 (IC50 = 0.29 and 0.49 µg/mL). Lipophilic extracts of Pothos scandens disp...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research