High-Resolution Probing of Early Events in Amyloid- β Aggregation Related to Alzheimer’s Disease

Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC01551B, Feature ArticleBikash Sahoo, Sarah N Cox, Ayyalusamy Ramamoorthy In Alzheimer ’s disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna in establishing the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research

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Resumo Prop ósito de vida (PV) é definido como o senso de que a vida tem sentido e intencionalidade, o qual desempenha papel orientador em relação às metas de vida e à tomada de decisões relativas ao uso dos recursos pessoais. Objetivos: reconhecer e analisar dados sobre PV e condições identificadas co m bom envelhecimento ou com adaptação positiva no envelhecimento. Método: foi realizada revisão integrativa de publicações de periódicos com avaliação por pares, indexadas nas bases de dados PubMed/Me...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
Using MRI, researchers have confirmed a link between high levels of a particular...Read more on AuntMinnie.comRelated Reading: MRI reveals brain changes in technologist with COVID-19 COVID-19 neuro findings marked by mental status, stroke MRI illuminates neurologic manifestations of COVID-19 AI predicts Alzheimer's disease using MRI, patient info AI system takes human approach to brain MRI diagnosis
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Development of Specific Fluorogenic Substrates for Human β-N-Acetyl-D-hexosaminidase A for Cell-Based Assays. Chem Pharm Bull (Tokyo). 2020;68(6):526-533 Authors: Miura K, Aoyama Y, Natsu Y, Koyama R, Hirano T, Nishio T, Hakamata W Abstract Inhibitors of human β-N-acetyl-D-hexosaminidase (hHEX) A and human O-GlcNAcase (hOGA) reportedly play roles in multiple diseases, suggesting their potential for pharmacological chaperone (PC) therapy of Sandhoff disease (SD) and Tay-Sachs disease (TSD), as lysosomal storage diseases, and Alzheimer's disease and progressive supranuclear palsy, respectively...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
A husband and wife team of Colombian scientists have observed Alzheimer's precursor molecules in cells taken from newborns – a boon for research into the earliest stages of a disease that doesn’t start to show symptoms until people are in their forties. #globalsouthscience
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Science /science Innovation /innovation Healthcare /healthcare Editors' Pick editors-pick Source Type: news
Until about 50 to 100 years ago, the tradition was to name diseases after the doctors who used to describe them for the first time. Such diseases are called eponymous diseases. There are numerous examples, such as Alzheimer’s disease, Marfan’s syndrome, and Wilson’s disease, to name a few. Often, specific signs and symptoms were named […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions COVID-19 coronavirus Infectious Disease Mobile health Source Type: blogs
Evidence strongly suggests that the global faltering of mitochondrial function throughout the body with advancing age has a lot to do with a decline in the effectiveness of mitophagy. Mitochondria are the power plants of the cell, a herd of hundreds swarming and replicating like bacteria in every cell to produce the chemical energy store molecule ATP. Mitophagy is the specialized form of autophagy that destroys worn and damaged mitochondria, recycling their component parts. Without it, cells would become overtaken by broken, malfunctioning mitochondria. Mitochondrial dysfunction leads to too little ATP, but also higher lev...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Van Andel Research Institute) Van Andel Institute scientists have revealed the first known atomic structure of a 'molecular machine' responsible for installing critical signaling proteins into cellular membranes. The findings, published today in Nature, shed new light on how this process works, and lay the foundation for potential future therapies for diseases like cancer, Alzheimer's and cystic fibrosis.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
by Nikhil Milind, Christoph Preuss, Annat Haber, Guruprasad Ananda, Shubhabrata Mukherjee, Cai John, Sarah Shapley, Benjamin A. Logsdon, Paul K. Crane, Gregory W. Carter Late-Onset Alzheimer’s disease (LOAD) is a common, complex genetic disorder well-known for its heterogeneous pathology. The genetic heterogeneity underlying common, complex diseases poses a major challenge for targeted therapies and the identification of novel disease-associated variants. Case-c ontrol approaches are often limited to examining a specific outcome in a group of heterogenous patients with different clinical characteristics. Here, we de...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractAlzheimer ’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and orientated towards cognitive or motor deficits. Neuropathologically, both are proteinopathies with pathological aggregates (plaques of amyloid-β pe ptide and neurofibrillary tangles of tau protein in Alzheimer’s disease, and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease). These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological stages. Both disorders...
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
ConclusionWe provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer ’s Disease patients from across Europe.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
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