Cognitively challenging agility boot camp program for freezing of gait in Parkinson disease - King LA, Mancini M, Smulders K, Harker G, Lapidus JA, Ramsey K, Carlson-Kuhta P, Fling BW, Nutt JG, Peterson DS, Horak FB.

Introduction. It is well documented that freezing of gait (FoG) episodes occur in situations that are mentally challenging, such as dual tasks, consistent with less automatic control of gait in people with Parkinson disease (PD) and FoG. However, mo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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Condition:   Parkinson Disease Interventions:   Other: Game based treadmill Program;   Other: Conventional Gait Rehabilitation Sponsors:   University of Manitoba;   Weston Brain Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(University of Cambridge) Researchers have uncovered a link between the structure of the protein alpha-synuclein and its likelihood to misfold and aggregate.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This study aimed to characterize the neurophysiological correlates of gait in the human pedunculopontine nucleus (PPN) region and the globus pallidus internus (GPi) in Parkinson’s disease (PD) cohort. Though much is known about the PPN region through animal studies, there are limited physiological recordings from ambulatory humans. The PPN has recently garnered interest as a potential deep brain stimulation (DBS) target for improving gait and freezing of gait (FoG) in PD. We used bidirectional neurostimulators to record from the human PPN region and GPi in a small cohort of severely affected PD subjects with FoG desp...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Sensors, Vol. 20, Pages 3189: An FPGA Based Tracking Implementation for Parkinson’s Patients Sensors doi: 10.3390/s20113189 Authors: Giuseppe Conti Marcos Quintana Pedro Malagón David Jiménez This paper presents a study on the optimization of the tracking system designed for patients with Parkinson’s disease tested at a day hospital center. The work performed significantly improves the efficiency of the computer vision based system in terms of energy consumption and hardware requirements. More specifically, it optimizes the performances of the background subtraction by segmenting...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Condition:   Parkinson's Disease Intervention:   Biological: Human Amniotic Epithelial Stem Cells Sponsors:   Shanghai East Hospital;   Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Melchionda D, Varvara G, Perfetto D, Mascolo B, Avolio C Abstract Parkinson's disease (PD), which is not only a motor disease, is one of the most frequent neurodegenerative diseases and affects 1.5-2% of people worldwide. The role of its non motor-symptoms is of first importance on quality of life. Speech impairment is considered a part of motor impairment and is widespread in PD where most frequent speech impairment is Hypokinetic dysarthria, a disorder characterized by reduced articulation movements and phonetic monotony. Many PD patients show difficulty in accessing the lexicon related to cognitive impa...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Mitochondrial dysfunction and neurodegeneration have been directly correlated in many neurodegenerative disorders. Parkinson’s disease (PD) in particular has been extensively studied in this context because of its well-characterized association with mitophagy, a selective type of autophagy that degrades mitochondria. Mitophagy is triggered by ubiquitin modification of proteins residing on the surface of mitochondria. Therefore, mitophagy is subject to suppression by deubiquitination. In recent years, many deubiquitinase enzymes (DUBs) emerged as therapeutic targets to compensate hindered mitophagy in PD. It is reason...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In conclusion, our study demonstrated that crocin protected the DA projection neurons in the VTA through activating mTOR, which subsequentl y improved the neural synaptic plasticity of mPFC, and ameliorated depression-like behavior in PD mice.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
ConclusionDespite the lack of statistical significance, when assessing the efficacy and safety outcomes for each drug in the evidence network, donepezil appeared to have a more favourable overall benefit/risk profile for patients with DLB. Further comparative trials are required to improve understanding of the true difference between existing and potential future treatment options.
Source: Neurology and Therapy - Category: Neurology Source Type: research
Authors: Lidstone SC, Bayley M, Lang AE Abstract INTRODUCTION: Parkinson's Disease (PD) is a chronic and slowly progressive neurodegenerative disease. Team-based care is required to address and manage the diverse array of motor and non-motor symptoms in PD and related conditions. As the evidence base for the efficacy of non-pharmacological treatment of PD is expanding, many different centers are implementing interdisciplinary models of care with allied health professionals trained in PD. AREAS COVERED: In this review, the authors outline these various models and review the evidence for multidisciplinary approaches ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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