GSE148279 Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Publication date: Available online 4 June 2020Source: Annals of Medicine and SurgeryAuthor(s): Yasser El Ghamrini, Tamer M.S. Salama, Mohamed I. Hassan, Haytham Mohamed Nasser
This study shows the complexity of genetic variation in predicting outcomes to treatment. We advocate for future replicative studies to potentially validate GSTA1 and CYP2C19 and definitively negate CYP3A4 and GSTP1 as biomarkers for risk of CROF after cyclophosphamide treatment. Understanding genetic variation in chemotherapy metabolism has the potential to individualise treatment regimens to maximise efficacy and minimise toxicity. PMID: 32496149 [PubMed - as supplied by publisher]
ConclusionsThe use of Kaiser score in high-risk MRI screening reliably excludes malignancy in more than 45% of contrast-enhancing lesions classified as BI-RADS 4.Key Points•The Kaiser score shows high diagnostic accuracy in identifying malignancy in contrast-enhancing lesions in patients undergoing high-risk screening for breast cancer.•The application of the Kaiser score may avoid> 45% of unnecessary breast biopsies in high-risk patients.•The Kaiser score aids decision-making in high-risk breast cancer MRI screening programs.
Publication date: 24 September 2020Source: Inorganica Chimica Acta, Volume 510Author(s): Thankaraj Salammal Sheena, Rajakumaran Dhivya, Venkatesan Rajiu, K. Jeganathan, Mallayan Palaniandavar, Ganesan Mathan, Mohammad Abdulkader Akbarsha
Authors: Ao H, Li Y, Li H, Wang Y, Han M, Guo Y, Shi R, Yue F, Wang X Abstract Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated their characterization, stability, hemolysis probability, release behavior in vitro, antitumor activity in vitro and in vivo, and preliminary safety through acute toxicity experiments. The resultant HGK nano...
Authors: Macruz CF, Lima SMRR, Postigo S, Martins MM, Lucarelli AP, de Oliveira VM Abstract OBJECTIVE: To assess quality of life and climacteric symptoms for post-menopausal women receiving hormone therapy for breast cancer. METHODS: A prospective observational study of women treated at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology was conducted between 2015 and 2019. Post-menopausal patients who had been diagnosed with breast cancer and who were experiencing climacteric symptoms were selected. These patients had undergone surgery, radiotherapy, and/or chemotherapy more than one...
Publication date: Available online 4 June 2020Source: Pathology - Research and PracticeAuthor(s): Wei Tang, Guo-Sheng Li, Jian-Di Li, Wen-Ya Pan, Qi Shi, Dan-Dan Xiong, Chao-Hua Mo, Jing-Jing Zeng, Gang Chen, Zhen-Bo Feng, Su-Ning Huang, Min-Hua Rong
Condition: HER2-positive Breast Cancer Interventions: Drug: Docetaxel; Drug: Carboplatin; Drug: Trastuzumab; Drug: Pertuzumab; Drug: Trastuzumab emtansine Sponsor: University of Rochester Not yet recruiting
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Breast Carcinoma; Refractory Breast Carcinoma Interventions: Drug: Cyclophosphamide; Biological: Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM; Biological: Pembrolizumab; Biological: Recombinant Interferon Alpha 2b-like Protein; Other: Questionnaire Administration; Other: Quality of...
Condition: Triple Negative Breast Cancer Interventions: Drug: epirubicin hydrochloride; Drug: Cyclophosphamide; Drug: Albumin bound paclitaxel; Drug: Toripalimab Sponsor: Fudan University Recruiting