Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice

Immune checkpoint inhibitors are effective in treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death 1 (PDCD1, also called PD1). We investigated mechanisms of resistance of liver tumors in mice to infiltrating T cells.

Source: Gastroenterology - April 6, 2020 Category: Gastroenterology Authors: David Kung-Chun Chiu, Vincent Wai-Hin Yuen, Jacinth Wing-Sum Cheu, Larry Lai Wei, Vox Ting, Michael Fehlings, Hermi Sumatoh, Alessandra Nardin, Evan W. Newell, Irene Oi-Lin Ng, Thomas Chung-Cheung Yau, Chun-Ming Wong, Carmen Chak-Lui Wong Source Type: research