PD-1, PD-L1 and BIM as predictors of sentinel lymph node metastasis in primary cutaneous melanoma

Current risk stratification methods for primary cutaneous melanoma are based on clinicopathologic variables and are limited in their ability to identify patients at risk of metastasis (Morton et al., 2014). It has previously been shown that other ways of characterizing melanoma such as using the tumor cell adhesion marker integrin β3 through immunohistochemistry (IHC) (Hieken et al., 1996) or quantitative reverse transcription polymerase chain reaction (qRT-PCR) (Meves et al., 2015) are useful in discriminating between primary cutaneous melanomas that had or had not metastasized, for example, to sentinel lymph nodes (SLN).

Source: Journal of Investigative Dermatology - April 6, 2020 Category: Dermatology Authors: Felix F. Kung, Suzette M. Arias-Mejias, Enrica Quattrocchi, Sindhuja Sominidi-Damodaran, Alina G. Bridges, Julia S. Lehman, Amy L. Weaver, Alexander Meves Tags: Letters to the Editor Source Type: research