Identification of Different Phenotypes of Esophageal Reflux Hypersensitivity and Implications for Treatment

Reflux hypersensitivity (RH), a functional esophageal disorder, is detected in 14% –20% of patients who present with typical esophageal symptoms. As many as 40% of patients with RH do not respond to treatment with pain modulators or proton pump inhibitors (PPIs); behavior disorders might contribute to lack of treatment efficacy. We aimed to assess the prevalence of behavioral di sorders and their effects on typical reflux symptoms in patients with RH.

Source: Clinical Gastroenterology and Hepatology - April 5, 2020 Category: Gastroenterology Authors: Akinari Sawada, Mauricio Guzman, Kornilia Nikaki, Shirley Sonmez, Etsuro Yazaki, Qasim Aziz, Philip Woodland, Benjamin Rogers, C. Prakash Gyawali, Daniel Sifrim Source Type: research