Protamine use in transcarotid artery revascularization is associated with lower risk of bleeding complications without higher risk of thromboembolic events

Recent studies have found that transcarotid artery revascularization (TCAR) is associated with lower risk of stroke or death compared with transfemoral carotid artery stenting but higher risk of bleeding complications, presumably associated with the need for an incision. Heparin anticoagulation is universally used during TCAR, so protamine use may reduce bleeding complications. However, the safety and effectiveness of protamine use in TCAR are unknown. We therefore evaluated the impact of protamine use on perioperative outcomes after TCAR in the Vascular Quality Initiative TCAR Surveillance Project.

Source: Journal of Vascular Surgery - April 5, 2020 Category: Surgery Authors: Patric Liang, Raghu L. Motaganahalli, Mahmoud B. Malas, Grace J. Wang, Jens Eldrup-Jorgensen, Jack L. Cronenwett, Brian W. Nolan, Vikram S. Kashyap, Marc L. Schermerhorn Source Type: research