Synthesis and antioxidant activity of new selenium-containing quinolines.

CONCLUSION: According to the obtained results 7-chloro-N(arylselanyl)quinolin-4-amines 5 were synthesized in good yields by the reaction of 4,7-dichloroquinoline with arylselanyl-amines and tolerates different substituents in the arylselanyl moiety. The tested compounds presented significant antioxidant potential in the tests of inhibition of DPPH, ABTS+ and NO radicals, as well as in the FRAP and superoxide dismutase-like activity assays (SOD-Like). PMID: 32242787 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32242787?dopt=Abstract

Source: Medicinal Chemistry - April 1, 2020 Category: Chemistry Authors: Bocchini B, Goldani B, Sousa FSS, Birmann PT, Brüning CA, Lenardão EJ, Santi C, Savegnago L, Alves D Tags: Med Chem Source Type: research