Acquired platelet dysfunction with eosinophilia in two patients

Acquired platelet dysfunction with eosinophilia (APDE) is a transient bleeding disorder characterized by spontaneous bruising in a healthy person. Spontaneous ecchymosis appears in 100% of patients with APDE.1 Other symptoms include epistaxis, gum or oral bleeding, gastrointestinal bleeding, hematuria, bleeding of the genital organs, subconjunctival hemorrhage, and excessive bleeding after tooth extraction. The diagnosis of APDE requires three elements: (1) clinical manifestation with spontaneous ecchymosis on the trunk or extremities, (2) hemogram showing eosinophilia, and (3) platelet dysfunction.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research