Practical Things You Should Know about Wound Healing and Vacuum-Assisted Closure Management

Learning Objectives: After reading this article, the participant should be able to: 1. Understand the basics of negative-pressure wound therapy and practical uses of various vacuum-assisted closure dressings. 2. Understand the mechanisms of action of negative-pressure therapies and other important adjuncts, such as perfusion imaging. 3. Discuss the evidence for hyperbaric oxygen therapy in wound care. Summary: Wound healing requires creating an environment that supports the healing process while decreasing inflammation and infection. Negative-pressure wound therapy has changed the way physicians manage acute and chronic wounds for more than 20 years. It contracts wound edges, removes exudate, including inflammatory and infectious material, and promotes angiogenesis and granulation tissue formation. These effects have been consistently demonstrated in multiple animal and human randomized controlled trials. Recent innovations that include instillation therapy and closed incision have further increased our arsenal against difficult-to-treat wounds and incisions at high risk of complications. Instillation of topical wound solutions allows physicians to cleanse the wound without return to the operating room, resulting in fewer debridements, shorter hospital stays, and faster time to wound closure. Other concepts have yielded negative-pressure therapy on top of closed surgical incisions, which holds incision edges together, reduces edema, promotes angiogenesis, and creates a b...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: CME Source Type: research

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Conclusion: PCMP demonstrated clinically meaningful benefits to patients with various types of cutaneous wounds. Clinical Trial registration number: NCT03286452. PMID: 32476449 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
1494Aim: To evaluate the added value of single-photon emission computerized tomography/computerized tomography (SPECT/CT) during technetium-99m-methyl diphosphonate (Tc-99m MDP) triple phase bone scan (TPBS) in assessment of underlying osteomyelitis in patients with stage IV pressure ulcers.Material and Methods: Retrospective review of TPBS in patients with stage IV pressure ulcers who had SPECT/CT imaging during scan late phase. We included 21 patients (mean age of 64.2±25.2 years; 16 males). Data included patients’ demographics, clinical findings, laboratory results as leukocytic count and ESR as well as bio...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research
AbstractChronic wounds may lead to the development of various pathological conditions such as diabetic foot ulcers and pressure sores. The current study evaluated wound healing and anti-inflammatory potentials of methanolic extract ofEphedra ciliata using series of in vivo models. Methanolic extract ofEphedra ciliata was prepared by maceration (Ec.Me). Qualitative and quantitative (HPLC) phytochemical and metal analyses were conducted to explore the chemical and metal profiles ofEc.Me. Safety profile (behavioural)  and, antimicrobial, antioxidant, wound healing, anti-inflammatory and anti-angiogenic potentials ofEc.Me...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
“Jinchuang ointment” is a traditional Chinese herbal medicine for external incised wounds. This herbal medicine has been successfully used to treat patients with diabetic foot ulcers and pressure sores in Taiw...
Source: Chinese Medicine - Category: Complementary Medicine Authors: Tags: Research Source Type: research
CONCLUSIONS: The combination of a collagen wound contact layer and weekly NPWT had a significantly positive effect on healing in this chronic DFU. The regimen was well-tolerated and simple to administer in this case. PMID: 32335522 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
This study found that hydrogel showed good results for the treatment of diabetic feet, reducing the area and overall PUSH score of the wounds.
Source: Plastic Surgical Nursing - Category: Nursing Tags: Departments Source Type: research
CONCLUSIONS: Use of advanced treatment modalities including NPWT, epidermal grafting, and ORC/collagen/silver-ORC dressings contributed to wound healing in these patients with complex and/or chronic wounds. PMID: 32155120 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Hypoxia inducible factor 1 (HIF-1) is known to be important in skin aging, involved in the regulation of numerous processes relevant to the maintenance and structure of skin tissue. One of these is the growth of blood vessels that is required for regeneration to take place following injury. The dysfunction of HIF-1 signaling and consequent dysfunction in blood vessel regrowth is a feature of the varieties of non-healing wounds that are observed in older people. The open access paper here reviews what is known of HIF-1 in this context. Oxygen is key to many processes of life and is involved in all stages of wound h...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Gentell Hydrogel Ag 4x4, model no. GEN-11420 - Product Usage: Under the care of a healthcare professional, Gentell Hydrogel Ag Saturated Gauze is indicated for partial and full thickness wounds, including pressure ulcers, venous stasis ulcers, diabetic ulcers, first and second degree burns and skin tears. It provides a moist wound environment for healing.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
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