Tripterigium glycoside fraction n2 ameliorates adriamycin-induced nephrotic syndrome in rats by suppressing apoptosis
Publication date: Available online 29 March 2020Source: Journal of EthnopharmacologyAuthor(s): Xiao-wan Wang, Rui-min Tian, Yi-qi Yang, Kai Wang, En-nian Li, Xiao-dong Han, Kun Bao, Wei Mao, Hong-tao Xu, Bo Liu, Peng Xu
ConclusionTolvaptan was very efficient in this case of hyponatremia associated with steroid-resistant NS. Tolvaptan should be considered in the management of therapy-resistant hyponatremia in patients with NS.
Publication date: Available online 21 May 2020Source: IDCasesAuthor(s): Mwelwa Chizinga, Manzar Hussain, Katie Taylor, Saminder Kalra, Asmita Gupte, Muna Canales
CONCLUSIONS: In patients of African ancestry, imported Plasmodium infection may be a new causal factor for secondary FSGS, particularly for collapsing glomerulopathy variants in an APOL1 high-risk variant background. PMID: 32444394 [PubMed - as supplied by publisher]
No abstract available
Background: Tacrolimus dosing is routinely tailored based on its trough level (C0) drawn by therapeutic drug monitoring in pediatric patients with primary nephrotic syndrome. However, this concentration is often inaccurate owing to inappropriate practice, such as deviation of sampling time (DST). The quantitative relationship between DST and C0 remains unclear. Methods: Tacrolimus concentration at nominal sampling times (12 hours after last dose) and 32 deviation scenarios (12 ± 4 hours every 15 minutes) was predicted using a previously validated population pharmacokinetic model based on 162 scenarios of 100 pr...
Conclusions. These findings suggest that genetic testing for inherited thrombophilia in NS could play an important role in detecting high-risk patients that warrant prophylactic anticoagulation. PMID: 32438633 [PubMed - in process]