Carotid Artery Dissection Induced Acute Tongue Swelling in a Cocaine User.
We report a 42-year old men who presented to our observation with acute tongue swelling and atrophy of left side of tongue from a hypoglossal nerve injury. A magnetic resonance imaging revealed a denervation of the left half of the tongue from a hypoglossal nerve injury due to left extracranial internal carotid artery (ICA) dissection, without evidence of ischemic stroke. The urine toxicology screen test revealed a positivity for cocaine. This case report suggest to perform in young patient a toxicological drug screening test in presence of ICA dissection with hypoglossal nerve injury and an acute tongue swelling. However clinical data must be performed to validate this observation and to analyze the negative effect of cocaine use. PMID: 32214522 [PubMed - in process]
BACKGROUND Patients with blunt cerebrovascular injuries are at risk of thromboembolic stroke. Although primary prevention with antithrombotic therapy is widely used in this setting, its effectiveness is not well defined and requires further investigation. The aim of this study was to evaluate the utility of magnetic resonance imaging (MRI)–detected ischemic brain lesions as a possible future outcome for randomized clinical trials in this patient population. METHODS This prospective observational study included 20 adult blunt trauma patients admitted to a level I trauma center with a screening neck CTA showing ex...
ConclusionOur study did not show worse outcomes in patients treated at off-hours. This result suggests that the off-hours effect reported in other studies can be minimized by a coordinated organisation of stroke care providing similar levels of care at off-hours.
CONCLUSIONS: Imaging, behavioral, and histological results suggested that LITUS stimulation after an ischemic stroke produced significant neuroprotective effects. PMID: 32439337 [PubMed - as supplied by publisher]
A 65-year-old man with a history of Wallenberg syndrome caused by vertebral artery dissection at 62 years old was admitted to our hospital with nausea, vertigo, right facial dysesthesia, right hemiplegia, crossed sensory disturbance (sensory loss and numbness in the right face and left body below the neck), and right limb ataxia. Magnetic resonance imaging (MRI) performed 80 minutes after onset revealed no acute ischemic stroke lesions, but magnetic resonance angiography (MRA) demonstrated complete occlusion of the right vertebral artery.
CONCLUSIONS: In the present cases, although ischemic stroke was serious and precluded surgical indication for ATAAD, carotid artery stenting before surgery for ATAAD resulted in good clinical outcomes. Performing carotid artery stenting before surgery for ATAAD is challenging but achievable, and is a valid treatment option depending on the individual cases. PMID: 32397860 [PubMed - as supplied by publisher]
Conclusion: The high payload of an aptamer conjugated bipyramidal FNA was for cerebral IRI management was provided by intrathecal injection. This DNA framework alleviated the extent of cerebral IRI by acting as an antioxidant and inhibitor of inflammation.
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Conclusions: The correlation between inflammation and neovascularization in carotid atherosclerotic plaques with hybrid 18F-FDG PET/MR varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. Hybrid 18F-FDG PET/MR systems can help to evaluate the correlation between inflammation and neovascularization in carotid atherosclerotic plaques. Key words: Atherosclerosis, Vulnerable plaque, Inflammation, Neovascularization, Hybrid PET/MR.
88Introduction: In addition to neurologic dysfunction, cerebral stroke increases risk of acute cardiac events and chronic heart failure. We hypothesized that inflammation is a linking mechanism, which can be interrogated by systems-based, multi-organ targeted positron emission tomography (PET). Methods: Cerebral ischemic stroke was induced in C57Bl6 mice by intraluminal transient 45 minute middle cerebral artery occlusion (MCAo, n=32) or after craniotomy using topical application of vasoconstrictor endothelin-1 (ET-1) (n=23). In controls, the intraluminal filament was immediately withdrawn (n=8) or a vehicle was applied af...
CONCLUSION: Not the whole process of coagulation function is associated with spontaneous HT. Prolonged TT, which may indicate an extension of the last step of the coagulation process, is independently and inversely associated with spontaneous HT in patients with acute ischemic stroke. PMID: 32407276 [PubMed - as supplied by publisher]