Rhabdoid morphology in gastrointestinal stromal tumours (GISTs) is associated with PDGFRA mutations but does not imply aggressive behaviour

ConclusionsRhabdoid gastric GISTs are associated with epithelioid morphology and PDGFRA mutations. They harbour CGH aberrations that are typical of ordinary GISTs in both tumour components. The presence of additional genetic alterations in the rhabdoid areas indicates evolution from the epithelioid components, and possible genetic and biological progression. On the basis of our series and previous reports, rhabdoid morphology in GISTs presumably does not imply aggressiveness.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fhis.12265

Source: Histopathology - November 22, 2013 Category: Pathology Authors: Inga‐Marie Schaefer, Philipp Ströbel, Silke Cameron, Alexander Beham, Claudia Otto, Hans‐Ulrich Schildhaus, Abbas Agaimy Tags: Original Article Source Type: research