Common cancer mutations R175H and R273H drive p53 DNA-binding domain towards aggregation-prone conformations

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/C9CP06671C, PaperLe Li, Xuhua Li, Yiming Tang, Zenghui Lao, Jiangtao Lei, Guanghong Wei The p53 protein is a tumor suppressor and the most often mutated protein in human cancers. Recent studies reported that p53 mutants, including two of the common cancer mutants (R175H... The content of this RSS Feed (c) The Royal Society of Chemistry
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