Characteristics, prognostic factors, outcomes in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival

Publication date: Available online 25 March 2020Source: Journal of OrthopaedicsAuthor(s): Muratori Francesco, Mondanelli Nicola, Pelagatti Lorenzo, Frenos Filippo, Matera Davide, Beltrami Giovanni, Innocenti Matteo, Capanna Rodolfo, Roselli Giuliana, Scoccianti Guido, Livi Lorenzo, Greto Daniela, Cristina Muntoni, Baldi Giacomo, Tamburini Angela, Campanacci Domenico Andrea
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research

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Conclusion: Radiomic analysis showed potential in differentiating OS from EWS of the pelvis, in which T2-FS demonstrated better diagnostic value. To differentiate OS from EWS of the pelvis using our multiparametric MRI-based radiomic analysis could preoperatively improve diagnostic accuracy and greatly contribute to therapy planning. PMID: 32462033 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
inerman Survival rates for Ewing sarcoma (ES) patients with metastatic disease have not improved in over 20 years. Tumor growth and metastasis are dependent on tumor vasculature expansion; therefore, identifying the regulators that control this process in ES may provide new therapeutic opportunities. ES expresses high levels of repressor element 1 silencing transcription factor (REST), which is regulated by the EWS-FLI-1 fusion gene. However, the role of REST in ES growth and the regulation of the tumor vasculature have not been elucidated. To study this role, we established REST-knockout human TC71 ES cell lines throu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
We report a rare case of primary spinal intramedullary Ewing-like sarcoma harboringCIC-DUX4 translocation. A 23-year-old man presented with weakness in the extremities. Magnetic resonance imaging revealed a large intramedullary tumor spanning C3 –C5 with heterogeneous enhancement following gadolinium administration. Histologically, most of the tumor displayed dense myeloid proliferation composed of medium- to slightly small-sized primitive cells. Postoperatively, he received local adjuvant radiation therapy without tumor progression for 1 0 months. Target RNA sequencing analysis revealed theCIC-DUX4 fusion gene....
Source: Brain Tumor Pathology - Category: Neurology Source Type: research
CONCLUSION: PET-CT may not have high sensitivity and specificity to identify bone marrow involvement for each type of cancer. The approach of using bone marrow biopsy and PET-CT as complementary modalities seems reliable. PMID: 32419409 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
Publication date: Available online 16 May 2020Source: European Journal of RadiologyAuthor(s): Dragana P. Sobic Saranovic, Marina Nikitovic, Jelena Saponjski, Isidora Grozdic Milojevic, Lejla Paripovic, Djordjije Saranovic, Slobodanka Beatovic, Vera M. Artiko
Source: European Journal of Radiology - Category: Radiology Source Type: research
NK3 homeobox 1 (NKX3-1) is widely accepted as a highly sensitive and specific marker for prostatic adenocarcinoma. Prompted by published transcriptome data showing upregulation of NKX3-1 mRNA expression in EWSR1-NFATC2 sarcoma, we explored the utility of NKX3-1 immunohistochemistry in sarcoma diagnosis. We applied NKX3-1 immunohistochemistry to 11 EWSR1-NFATC2 sarcomas and 168 mimics using whole tissue sections. All EWSR1-NFATC2 sarcomas consisted of uniform small round or ovoid cells, all except 1 showing at least focally the typical growth pattern of nests, cords, or trabeculae within a fibrous/myxoid background. A varia...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Publication date: Available online 12 May 2020Source: Journal of the American Society of CytopathologyAuthor(s): Daniel L. Miller, Sinchita Roy-Chowdhuri, Peter Illei, Aaaron James, Ralph H. Hruban, Syed Z. Ali
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
We report 3-year disease control and toxicity in pediatric patients treated with proton therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
In randomized controlled trials (RCTs) of adjuvant treatment for malignant tumors, event-free survival (EFS) is considered the most acceptable surrogate for overall survival (OS). However, even though EFS has ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Abstract A 21-year-old male Army basic trainee was evaluated in a direct-access physical therapy clinic for left-sided low back pain. Following examination, radiographs and a bone scan were ordered. The findings prompted referral for a computed tomography scan of the pelvis, which characterized an infiltrative soft tissue mass. The therapist immediately contacted an orthopaedic surgeon, who recommended that the physical therapist order immediate magnetic resonance imaging (STAT MRI). The patient underwent a tissue biopsy and subsequently was diagnosed with Ewing's sarcoma. J Orthop Sports Phys Ther 2020;50(5):276....
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Orthop Sports Phys Ther Source Type: research
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