Molecules, Vol. 25, Pages 1454: Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

Molecules, Vol. 25, Pages 1454: Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.
Molecules doi: 10.3390/molecules25061454
Authors:
Rosa Mariana Montiel-Ruiz
Marcos Córdova-de la Cruz
Manasés González-Cortázar
Alejandro Zamilpa
Abraham Gómez-Rivera
Ricardo López-Rodríguez
Carlos Ernesto Lobato-García
Ever A. Blé-González

Aristolochia odoratissima L. is employed for the treatment of pain and as an antidote against the poison of venomous animals in traditional medicine. However, reports have not been found, to our knowledge, about the evaluation of the antinociceptive activity of extracts nor about the presence of compounds associated with this activity. Thus, the purpose of this work was to evaluate the antinociceptive activity of extracts and compounds isolated from the stems of Artistolochia odoratissima L. The extracts were obtained with solvents of increasing polarity and the compounds were isolated and characterized by column chromatography, HPLC, and NMR. The antinociceptive activity was carried out by the formalin test in mice. Ethyl acetate (AoEA) and methanolic (AoM) extracts decreased the paw licking in both phases of the formalin test. The isolated compounds (kaurenoic acid and hinokinin) from AoEA showed the highest antinociceptive activity in both phases of the formalin test. These results confirmed the analgesic effect of this specie described in traditional medicine and provided a ba...

Source: Molecules - March 23, 2020 Category: Chemistry Authors: Rosa Mariana Montiel-Ruiz Marcos C órdova-de la Cruz Manas és González-Cortázar Alejandro Zamilpa Abraham G ómez-Rivera Ricardo L ópez-Rodríguez Carlos Ernesto Lobato-Garc ía Ever A. Bl é-González Tags: Article Source Type: research