Africa: New, Shorter Treatment to Prevent TB to be Rolled out in Five High-Burden TB Countries

[Aurum Institute] Johannesburg -Three-month regimen expected to prevent TB in those at highest risk of developing the disease, including people living with HIV and children under the age of five
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news

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Conditions:   TB - Tuberculosis;   Patient Satisfaction Intervention:   Behavioral: Patient-centred advice on Telephone Consultation in TB Patients: Sponsors:   Health Science Center of Xi’an Jiaotong University;   Pakistan Institute of Medical Sciences Islamabad Pakistan;   District Headquarter Hospital Bannu Pakistan Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT01365J, PerspectiveLuiz Gonzaga Fran ça de França Lopes, Edinilton Muniz Carvalho, Eduardo Henrique Silva Sousa Medicinal inorganic chemists have provided many strategies to tackle a myriad of diseases, pushing forward the frontiers of pharmacology. As an example, the fight against tuberculosis (TB), an infectious bacterial... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Lebogang Kenaope, Hannetjie Ferreira, Faheem Seedat, Kennedy Otwombe, Neil A. Martinson, Ebrahim Variava
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
We studied the response of the extracellular matrix of the lungs and liver in mice with BCGinduced granulomatosis (3 months) after inhalation and intraperitoneal administration of liposome-encapsulated dextrazide (LEDZ): a conjugate of oxidized dextran (40 kDa) and isonicotinic acid hydrazide (INH). LEDZ inhalation proved to be more effective in reducing fibrosis severity, both in the lungs and liver. However, the mechanisms of the antifibrotic effect were different: increased degradation and reduced collagen synthesis in the lungs and reduced collagen synthesis and collagen degradation in the liver. This suggest that drug...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Experimental studies of Perchlozone, an antituberculous drug with manifest inhibitory activity towardsMycobacterium tuberculosis andMycobacterium bovis, were carried out. Genotoxicity of Perchlozone was evaluated by the DNA comet method on liver and lung tissues and blood cells after 14-day inhalation exposure of rats. The level of DNA aberrations in response to inhalations of the drug in a concentration of 102.6 ±13.7 mg/m3 increased in lung tissue but not in the blood cells or liver. These results indicated genotoxic activity of antituberculous drug Perchlozone.
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Prabir Kumar ChatterjeeIndian Journal of Public Health 2020 64(6):102-104 At the end of April 2020, there had already been three million cases of COVID-19 in the world pandemic. Chhattisgarh might expect 90,000 diagnosed cases of COVID-19 in the end. The first step taken in March was to ensure a simple checklist of activities that needed to continue. Handbills were given with the basic information on the symptoms and what to do in the community. In urban areas, the lockdown affected the poorer section of the society, especially who are not having BPL card and no other means of availing necessary eatables. Issues that aros...
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis worldwide and kills more Americans than 59 other infections, including HIV and tuberculosis, combined. While direct-acting antiviral (DAA) treatments are effective, limited uptake of therapy, particularly in high-risk groups, remains a substantial barrier to eliminating HCV. We developed...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physical Sciences Source Type: research
In this study, we present three cases of testicular infarction and discuss their clinical characteristics, imaging features and clinical management. PATIENTS AND METHODS: Three adult males with prolonged epididymitis presented with chronic unilateral testicular pain, tenderness, and palpable swelling, including left varicocele in one case and hydrocele in the other two cases. Patient's symptoms were not relieved after antibiotic therapy. We analyzed the diagnosis, management, and outcome of these three cases of testicular infarction resulting from prolonged epididymitis. This includes the clinical characteristics, feat...
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
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Source: Journal of Agromedicine - Category: Environmental Health Authors: Source Type: research
Mucosal Immunology, Published online: 01 June 2020; doi:10.1038/s41385-020-0300-zGranulocytes act as a niche for Mycobacterium tuberculosis growth
Source: Mucosal Immunology - Category: Allergy & Immunology Authors: Source Type: research
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