Effects of the thermal denaturation of Sabin-derived inactivated polio vaccines on the D-antigenicity and the immunogenicity in rats.

Effects of the thermal denaturation of Sabin-derived inactivated polio vaccines on the D-antigenicity and the immunogenicity in rats. Vaccine. 2020 Mar 17;: Authors: Murakami K, Fujii Y, Someya Y Abstract The efficacy of a Sabin-derived inactivated polio vaccine (sIPV) can be evaluated by measuring the immunogenicity and the contents of D-antigens, which induce the neutralizing antibodies. The immunogenic potency test in rats was done as a national assay in Japan. The two manufacturers of sIPV in Japan have performed both assays since development, and there is no clear discrepancy between the results obtained in the two assays. To further know the relationship between the two assays, we analyzed the effects of the heat treatment of sIPV on the D-antigenicity and the immunogenicity. We observed that the marginal D-antigen that remained after the thermal treatment was capable of inducing relatively high neutralizing antibodies in rats. This indicates that the measurement of the D-antigen contents as part of the quality control of sIPV is more sensitive and appropriate to detect denatured vaccines. PMID: 32197923 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

Related Links:

From 2018-2019, the Bill and Melinda Gates Foundation gave more money to the World Health Organization than any entity except the U.S. government. With President Donald Trump cutting ties to the international health agency in the midst of the COVID-19 pandemic, the Gates Foundation’s work has come into sharper relief than ever. Co-chair Bill Gates announced at the Global Vaccine Summit on June 4 that it will give $1.6 billion over five years to the Vaccine Alliance (GAVI), to help ensure that people around the world have access to vaccines, regardless of income. The Gates Foundation in 1999 pledged $750 million to he...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Vaccines have played a critical role in reducing the spread of, and in some cases, eliminating the threat of many devastating infectious diseases. They are often cited as second only to clean drinking water in leading to some of the most impactful public health advances in history, including the eradication of smallpox and near global elimination of polio.
Source: The Catalyst - Category: Pharmaceuticals Tags: Research and Development Vaccines New Era of Medicine & D Focus Coronavirus Source Type: news
This week ’s Global Vaccine Summit comes at a crucial point in history. Governments must not miss their chance to save livesCoronavirus – latest updatesSee all our coronavirus coverageGro Harlem Brundtland is former director-general of the World Health OrganizationElizabeth Cousens is president of the UN FoundationGoogle any list of the most successful public health interventions of this century or the last, and vaccines will be at the very top. Infectious diseases such as smallpox, measles, diphtheria and pertussis (whooping cough) were once prevalent and killed indiscriminately. Smallpox is now eradicated, po...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Vaccines and immunisation Coronavirus outbreak Infectious diseases Medical research Science World Health Organization Polio World news Source Type: news
Some 80 million children worldwide could be at risk of vaccine-preventable diseases like diphtheria, measles and polio due to disruption of routine immunization during the COVID-19 pandemic, UN agencies and the GAVI vaccine alliance said on Friday.Reuters Health Information
Source: Medscape Pediatrics Headlines - Category: Pediatrics Tags: Infectious Diseases News Source Type: news
By Anis Chowdhury and Jomo Kwame SundaramSYDNEY and KUALA LUMPUR, May 26 2020 (IPS) With well over five million Covid-19 infections worldwide, and deaths exceeding 340,000, the race for an effective vaccine has accelerated since the SARS-Cov-2 virus was first identified as the culprit. Expecting to score politically from being ‘first’ to have a vaccine, US President Trump’s Operation Warp Speed promises to get 300 million doses to Americans by January, after the November polls, following several failed attempts to monopolize vaccines being developed by European companies. Anis Chowdhury More than 115 vac...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Economy & Trade Featured Global Headlines Health Humanitarian Emergencies TerraViva United Nations Jomo Kwame Sundaram & Anis Chowdhury Source Type: news
Abstract INTRODUCTION: Pakistan is suffering from low routine childhood immunization (RI) coverage, meriting a systematic examination of community acceptance and barriers towards vaccination with a view to inform responsive strategies. We examine community perspectives on RI for children 0-23 months of age, unveiling community beliefs, health systems barriers and willingness to actively seek immunization services. METHODS: A qualitative study was conducted in the rural under-resourced district of Tando Muhammad Khan of Pakistan's Sindh province. 12 focus group discussions were conducted to probe immuniza...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
In the 1950s, as Dr. Jonas Salk and virologist Albert Sabin worked to create a vaccine to prevent infantile paralysis, the threat from polio was already long familiar to Americans. (Image credit: AP)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
[WHO] Geneva -Agencies call for joint effort to safely deliver routine immunization and proceed with vaccination campaigns against deadly vaccine-preventable diseases.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
A new study of 129 countries found that the interruption of inoculation efforts could put 80 million babies at risk of getting deadly, preventable diseases.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Measles Poliomyelitis Vaccination and Immunization Medicine and Health Preventive Medicine Children and Childhood Third World and Developing Countries Gavi, the Vaccine Alliance World Health Organization United Source Type: news
This study goes beyond previous work to provide a detailed comprehensive evaluation of the enterovirus surveillance and can be used to formulate a set of implementation plan and performance indicators for environmental surveillance. PMID: 32444474 [PubMed - as supplied by publisher]
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
More News: Allergy & Immunology | Japan Health | Polio | Polio Vaccine | Vaccines