Measuring vs Estimating LDL-C Levels in a Clinical Trial of Bempedoic Acid —Reply

In Reply Drs Xu and Pan comment that the Friedewald formula used for calculating LDL-C levels is not as accurate as direct LDL-C measurement and that our study should have used the latter methodology. Although it is true that methodology improves over time and that there are new methods under exploration that may be more sensitive, those methods have not yet been widely adopted in clinical practice or investigational research. The methods used in our study were consistent with the current gold standard and with the way clinical trial data are typically reported.
Source: JAMA - Category: General Medicine Source Type: research