In vitro activity of isavuconazole against three species of Acanthamoeba.

In vitro activity of isavuconazole against three species of Acanthamoeba. J Fr Ophtalmol. 2020 Mar 06;: Authors: Brunet K, Eestermans R, Rodier MH, Cateau E Abstract Acanthamoeba keratitis due to a genus of free-living amoebae is a severe corneal infection. Treatment of this disease is based on the combined use of antiseptics and other drugs, including azoles. We tested isavuconazole, the latest marketed azole, in vitro, against A. castellanii, A. lenticulata and A. hatchetti. Our results show that isavuconazole presents slight amoebistatic activity against A. castellanii trophozoites but no cysticidal activity. Isavuconazole could be used only in association for management of AK due to A. castellanii. PMID: 32151474 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research