Accurate 3-gene-signature for early diagnosis of liposarcoma progression

ConclusionsThe identified metabolic signature allows highly accurate differential diagnosis between WD- and DDLPS even in samples containing lipid droplets, a marker of differentiation, which makes it very suitable for the use on biopsies. In respect to the pathogenesis of the disease, our results give a new insight into possible molecular mechanisms involved and support the recent observation that deletion ofPNPLA2 is a novel factor in liposarcoma progression.
Source: Clinical Sarcoma Research - Category: Cancer & Oncology Source Type: research