Co-administration of Paediatric Medicines with Food and Drinks in the Context of Their Physicochemical Properties —a Global Perspective on Practices and Recommendations

This study used a defined search strategy on the practices of paediatric medicine co-administration with vehicles, recommended in a commonly used paediatric and neonatal handbook, in addition to the information previously gathered from UK formularies. Logistic regression analysis was performed to further understand the biopharmaceutical basis of the choice of recommended vehicle for medicine co-administration. Differences were identified in the type of vehicles globally recommended for medicine co-administration. Ultimately, a statistical model was developed which provided an understanding on which vehicle is recommended for use with drugs/formulations, with basis on their biopharmaceutical properties. Overall, this review highlights the areas where further information is needed to support standardised procedures and guide the recommendation of age-appropriate and acceptable vehicles for use in the co-administration of paediatric medicines. Unified requirements are needed for harmonisation of the practice of medicine co-administration with vehicles.In vitro and/orin silico tools should be developed to evaluate the potential clinical outcomes of this practice during paediatric drug development.
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research