Inhibitor binding sites in the protein tyrosine phosphatase SHP-2.

Inhibitor binding sites in the protein tyrosine phosphatase SHP-2.
Mini Rev Med Chem. 2020 Mar 03;:
Authors: Zhang H, Gao Z, Meng C, Li X, Shi D
Abstract
Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of selective SHP-2 inhibitors. In this review, we describe the binding modes of existing inhibitors and SHP-2 binding sites, summarize the characteristics of the sites involved in selectivity, and identify the suitable groups for interaction with the binding sites.
PMID: 32124695 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - March 2, 2020 Category: Chemistry Authors: Zhang H, Gao Z, Meng C, Li X, Shi D Tags: Mini Rev Med Chem Source Type: research