Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells.

In conclusion, rhythmic expressions of five human CYPs (CYP1A2, 2B6, 2C8, 2E1 and 3A4) are generated and regulated by E-box-, D-box-, and/or RevRE-acting clock components. Our findings may have implications for understanding chronopharmacokinetic events in humans.
PMID: 32118505 [PubMed - as supplied by publisher]

Source: Xenobiotica - March 1, 2020 Category: Research Authors: Chen M, Zhou C, Zhang T, Wu B Tags: Xenobiotica Source Type: research