Autologous blood derived signaling proteins (sp) for tendon and muscle therapy in sports medicine. Higher concentration of growth factors (gf) and cytokines in orthokine vs in acp.

Discussion: Oe and Ax are used clinically. Degranulating platelets and other blood cells contribute to blood borne GF and cytokine output. Oe gains from all blood cells. Ax gains from 85% platelets. Oe's high IL-1Ra and GFs explain its profound (anti-inflammatory) action [Wehling et al. Biodrugs 2007;21(5):323-332]. Ax is not PRP, provides less SP than Oe. Muscle and tendon repair with Oe has been shown [Heisterbach et al. KSSTA 2012;10:1907-14, Majewski et al. Am J Sports Med 2009;11:2117-25, Wright-Carpenter et al. Int J Sports Med 2004;25:582-587 & 588-593]. Oe and Ax are used in joint treatment also. Oe has 2 y efficacy in high-pain OA [Baltzer et al. Osteoarthritis Cartilage 2009;17(2):152-160]. Autologous blood preparations are safe and, by WADA, not doping. ORTHOKINE(®) registered trademark of ORTHOGEN Inc. ARTHREX(®) ACP registered Trademark of ARTHREX Inc. PMID: 24159103 [PubMed - in process]
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Br J Sports Med Source Type: research